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EC number: 948-766-3 | CAS number: -
Labeled paraffins with 8-18 C atoms prepared from unsaturated hydrocarbons by addition of deuterium have been added in oily solution to normal rats’ food. After six days an increase of deuterium content in the body fluid of all the rats was observed indicating that the labeled compounds had been metabolized. Deuterium was found in the fatty acids of the body fats and the liver lipids especially after feeding octadecane and hexadecane. Isolating oleic, stearic, and palmitic acids containing deuterium, indicated that methyl- and beta-oxidation of these hydrocarbons has occurred. Fatty acids resulting from the metabolism of hydrocarbons with shorter chains were not deposited but in these cases the urine contained fatty acids with higher deutrium content than after administration of octadecane and hexadecane. According to the deuterium content of the neutral fractions from the liver and body lipids all the hydrocarbons tested were deposited only to a small extent, the largest depots occurring mainly after feeding with octadecane and hexadecane.
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