Registration Dossier
Registration Dossier
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EC number: 203-298-2 | CAS number: 105-44-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-01-05 to 2018-01-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- 4-methylpentan-2-one oxime
- EC Number:
- 203-298-2
- EC Name:
- 4-methylpentan-2-one oxime
- Cas Number:
- 105-44-2
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 4-methylpentan-2-one oxime
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 2017 494
Results and discussion
Water solubility
- Key result
- Water solubility:
- 12.158 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- pH:
- >= 8.31 - <= 8.67
- Remarks on result:
- other: mean of 3 runs
- Remarks:
- oven temperature: 40°C
Any other information on results incl. tables
Preliminary estimation:
| Mass of sample (mg) | Volume of water in which sample dissolves (mL) | Estimated solubility (g/L) |
| 10000 | 1000 | 10 -50 |
Main study:
Two peaks were detected in each of the three flasks.
The analysis assumes that the test material is 100% pure.
The HPLC analysis indicated two major peaks in the chromatogram.
These have been taken to be the geometric isomers of the oxime (syn- and anti- forms).
Applicant's summary and conclusion
- Conclusions:
- The flask method was applied for the determination of the water solubility
The water solubility of the test item at 40°C was 12.158 g/L.
The pH-range of the aqueous samples was 8.31-8.67
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