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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 17 October 2018 and 19 October 2018.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 4,5 and 6 July 2016/ Signed on 10 January 2017
Type of method:
static method
Key result
Temp.:
20 °C
Vapour pressure:
2 474 Pa
Key result
Temp.:
25 °C
Vapour pressure:
2 825 Pa

Results:

For each experimental temperature (T), log10(p) was calculated from the mean of measured values. A vapour pressure curve was obtained by plotting log10(p) against (1/T), with p in Pa and T in K.

A linear regression was obtained and the vapour pressure of the substance has been calculated at 20°C or 25°C.

Time (hh:mm)

Pressure (Pa)

Temperature (°C)

10:31

2270

20.1

11:36

2628

24.1

12:28

2959

28.1

13:38

3332

32.1

14:23

3708

36.1

15:19

3457

32.1

16:16

3197

28.1

17:33

2928

24.1

19:00

2650

20.1

Data exploitation

Vapour Pressure* (Pa)

Corresponding Temperature (°C)

Temperature (K)

1/T (K-1)

Log10(p)

2460

20.1

293.25

3.410E-03

3.391

2778

24.1

297.25

3.364E-03

3.444

3078

28.1

301.25

3.320E-03

3.488

3395

32.1

305.25

3.276E-03

3.531

3708

36.1

309.25

3.234E-03

3.569

*: mean of pressures values for increasing and decreasing temperature if available.

 

A plot of Log10(p) versus reciprocal temperature (1/T) (with p in Pa and T in K) gives the following statistical data using an unweighted least square treatment.

 

Slope              -1006.3

Intercept         6.8263

R²                   0.998

 

The results obtained indicate the following vapour pressure relationship:

 

Log10(p (Pa)) = -1006.3 / T (K) +6.8263

 

The above equation yields a vapour pressure of 2474 Pa at 293.15 K and 2825 Pa at 298.15 K.

Conclusions:
The vapour pressure of the test substance is 2474 Pa at 20°C and 2825 Pa at 25°C.
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, static method. Temperature/vapour pressure were used to calculate a regression in a temperature range of 20.1 – 36.1 °C, from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 2474 Pa at 20.0 °C and 2825 Pa at 25 °C.

These values represent the component with the highest vapour pressure.

Description of key information

The vapour pressure of the test substance is 2474 Pa at 20°C and 2825 Pa at 25°C (interpolation).

These values represent the component with the highest vapour pressure (worst case).

Key value for chemical safety assessment

Vapour pressure:
2 825 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data for purpose of CSA.