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EC number: 916-899-6 | CAS number: -
Corrected inhalatory NOAEC = oral NOAEL * 1/0.38 m3 kg-1 * 6.7/10
There are no quantitative oral or inhalation absorption rates available. Based on the log Pow in the range of 1.82 -3.72, the high water solubility, and the information that absorption occurs following oral exposure, absorption by the respiratory tract is likely and can be assumed to be in the same range than oral absorption. Therefore, no further factor for absorption differences oral to inhalation is introduced.
No further factors is introduced for absorption differences extrapolation oral to dermal, because it can be assumed that absorption after dermal exposure will not be higher than after oral exposure (e.g. molecular weight in a range not favourable for dermal absorption).
Contact to the skin is the relevant route to be assessed for workers. Inhalation exposure is unlikely, since the vapour pressure of the substance is calculated to be negligible at ambient temperature.
In the available Combined Repeated Dose toxicity study with the Reproduction/ Developmental Toxicity Screening (OECD TG 422) with oral exposure the substance was generally well tolerated by the rats. The kidney was identified as the primary target organ with adverse effects reported in males and females given 1000 mg/kg bw (degeneration of the tubular epithelium in both sexes and tubular basophilia in males). The NOAEL was concluded to be at the next lower dose, i.e. 330 mg/kg bw. This study is used as the point of departion for a DNEL delineation, unless further data will become available (a testing proposal of an OECD TG 408 is included in this dossier).
Since only systemic advers effects were revealed in that study route to route extrapolation from oral to dermal and from oral to inhalation is possible, and is applied (for further explanations and assessment factors see DNEL endpoint-specific fields).
Corrected inhalatory NOAEC = oral NOAEL * 1/1.15 m3 kg-1
Oral ingestion and contact to the skin are the relevant routes to be assessed for the general population. Inhalation exposure is unlikely, since the vapour pressure of the substance is calculated to be negligible at ambient temperature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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