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EC number: 916-899-6 | CAS number: -
It has to be clarified that the positive levels are exclusively difined for the NMRI mice used for this study:
The positive level of ear swelllling which is 2x10 [exp -2] mm increase , i.e. about 10 % of the control values, has not been reached or exceeded in any dose groups of the test item whereas the respective value of the positive control has shown a statistical significant increase.
body weights of the animals was not affected by any treatment.
A LLNA/IMDS was carried out in female NMRI mice after epicutaneous application of formulation containing 0%, 2.5 %, 10 %, or 41.2 % of the test item Bayscript Blaukomponenten in DMF for 3 consecutive days onto both ears of the animals. The study was conducted according to OECD TG No. 429 and No 406. Bayscript Blaukomponente showed no sensitizing potential in the modified Local Lymph Node Assay (IMDS) in female NMRI mice after dermal application of up to and including a 41.2 % concentration. Additionally, no indication for a non-specific(irritant) activation by the test item was detected. The positive control hexyl cinnamic aldehyde (CAS-No. 101 -86 -0) was functional for each parameter (Vohr 2012). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
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