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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 Feb 2018 to 28 Mar 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
The Department of Health of the Government of the United Kingdom
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
542.128 µm
Geometric standard deviation:
>= 2.03 - <= 2.077
Percentile:
D10
Mean:
156.275 µm
St. dev.:
4.308
Percentile:
D50
Mean:
442.645 µm
St. dev.:
7.751
Percentile:
D90
Mean:
835.414 µm
St. dev.:
16.35

Full Test Results

 

RUN1

RUN2

RUN3

RUN4

RUN5

Average**

Volume weighted mean

481.172

476.077

460.788

468.169

485.309

474.303

Median

450.131

444.102

429.932

438.717

450.719

442.645

Mode

512.821

507.324

494.747

505.640

513.985

506.850

MMAD*

551.296

543.911

526.557

537.316

522.016

542.128

d10(10% of material is<)

161.912

157.704

150.567

152.321

159.567

156.275

d50(50% of material is<)

450.131

444.102

429.932

438.717

450.719

442.645

d90(90% of material is<)

843.609

838.978

812.708

822.288

859.267

835.414

All results are in µm

* Mass median aerodynamic diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

0.0 % by volume of sample was seen to be < 10.00 µm.

Standard Deviation results

RunNo.

1

2

3

4

5

STDVP

%STDVP

d10(10%of material is<)

161.912

157.704

150.567

152.321

159.567

4.308

2.8

d50(50%of material is<)

450.131

444.102

429.932

438.717

450.719

7.751

1.8

d90(90%of material is<)

843.609

838.978

812.708

822.288

859.267

16.350

2.0

d15.78(15.78%of material is<)

221.780

216.259

207.013

211.215

218.705

5.280

2.5

GSD

2.030

2.054

2.077

2.077

2.061

0.018

0.9

MMAD

551.296

543.911

526.557

537.316

522.016

10.796

2.0

GSD = Geometric standard dev. of the lognormal particle size distribution (calculated from d50/d15.78)

STDVP = standard deviation of the population

% STDVP = percentage standard deviation of the population

 

Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.

 

Description of key information

d10 is 156.275 µm (ISO 13320, laser diffraction)

d50 is 442.645 µm (ISO 13320, laser diffraction)

d90 is 835.414 µm (ISO 13320, laser diffraction)

Additional information