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EC number: 244-121-9 | CAS number: 20941-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrakis(diethyldithiocarbamato-S,S')tellurium
- EC Number:
- 244-121-9
- EC Name:
- Tetrakis(diethyldithiocarbamato-S,S')tellurium
- Cas Number:
- 20941-65-5
- Molecular formula:
- C20H40N4S8Te
- IUPAC Name:
- N2,N2,N6,N6,N6,N6,N9,N9-octaethyl-1λ³,3,5λ³,5λ³,7,7,8λ³,10-octathia-4λ⁸-telluradispiro[3.3⁴.3⁴.3⁴]trideca-1,5,5,8-tetraene-2,6,6,9-tetramine
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name of the test item (as cited in study report): Tellurium diethyldithiocarbamate
- Batch No.: MT-5D 494
- Appearance: Yellow, powder
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd., Manston Road, Margate, Kent, England
- Weight at study initiationt: 282-300g for males and 237-250 for females
- Age at study initiation: 4-6 weeks
- Housing: Rats were housed individually in metal cages with wire mesh floors
- Diet: Labsure LAD 1 (ad libitum)
- Water: tap water (ad libitum)
- Acclimation period: 7 days
ENVIRONMENT
- Temperature: 20-22 °C
- Humidity: 63%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- A group of ten rats (five males and five females) was treated with a single dose of 5 g/kg bw. The test substance was prepared at 50% w/v in distilled water and administered at a volume of 10.0 ml/kg
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of examination: Twice daily for clinical signs. On Days 1, 2, 3, 5, 8, 11 and 15, body weight was measured
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities following a single oral dose of test substance at 5.0 g/kg bodyweight.
- Clinical signs:
- other: Pilo-erection was seen in all rats shortly after dosing. On Day 2 soft faeces were observed for all animals. No other signs of reaction to treatment were observed. Recovery was judged by external appearance and behaviour was apparently complete by Day 3.
- Gross pathology:
- Terminal autopsy findings were normal.
Any other information on results incl. tables
TABLE 1 Individual bodyweights (g) of rats dosed orally with tellurium diethyldithiocarbamate
Sex |
Bodyweight (g) at Day |
||||||
1 |
2 |
3 |
5 |
8 |
11 |
15 |
|
m |
282 286 296 300 299 |
315 304 318 320 319 |
309 295 326 340 329 |
328 320 346 355 354 |
339 336 366 377 378 |
353 354 398 390 402 |
366 370 424 409 430 |
f |
242 244 240 237 250 |
264 259 252 250 263 |
256 253 251 243 275 |
270 260 250 250 277 |
273 265 263 252 285 |
276 274 264 268 293 |
280 277 264 267 305 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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