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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(diethyldithiocarbamato-S,S')tellurium
EC Number:
244-121-9
EC Name:
Tetrakis(diethyldithiocarbamato-S,S')tellurium
Cas Number:
20941-65-5
Molecular formula:
C20H40N4S8Te
IUPAC Name:
tetrakis(diethyldithiocarbamato-S,S')tellurium
Test material form:
solid
Specific details on test material used for the study:
- Name of the test item (as cited in study report): Tellurium diethyldithiocarbamate
- Batch No.: MT-5D 494
- Appearance: Yellow, powder

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River (UK) Ltd., Manston Road, Margate, Kent, England
- Weight at study initiationt: 282-300g for males and 237-250 for females
- Age at study initiation: 4-6 weeks
- Housing: Rats were housed individually in metal cages with wire mesh floors
- Diet: Labsure LAD 1 (ad libitum)
- Water: tap water (ad libitum)
- Acclimation period: 7 days

ENVIRONMENT
- Temperature: 20-22 °C
- Humidity: 63%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
A group of ten rats (five males and five females) was treated with a single dose of 5 g/kg bw. The test substance was prepared at 50% w/v in distilled water and administered at a volume of 10.0 ml/kg
Doses:
5 g/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of examination: Twice daily for clinical signs. On Days 1, 2, 3, 5, 8, 11 and 15, body weight was measured
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
There were no mortalities following a single oral dose of test substance at 5.0 g/kg bodyweight.
Clinical signs:
Pilo-erection was seen in all rats shortly after dosing. On Day 2 soft faeces were observed for all animals. No other signs of reaction to treatment were observed. Recovery was judged by external appearance and behaviour was apparently complete by Day 3.
Body weight:
Bodyweight losses were recorded for two male and four female rats on Day 3, one female rat on Day 5 and one female rat on Day 15. An unchanged bodyweight was recorded for one female rat on Day 15. Bodyweight gains were recorded on all other occasions.
Gross pathology:
Terminal autopsy findings were normal.

Any other information on results incl. tables

TABLE 1 Individual bodyweights (g) of rats dosed orally with tellurium diethyldithiocarbamate

 

Sex

Bodyweight (g) at Day

1

2

3

5

8

11

15

m

282 286 296 300 299

315 304 318 320 319

309 295 326 340 329

328 320 346 355 354

339 336 366 377 378

353

354

398

390

402

366 370 424 409 430

f

242 244 240 237 250

264 259 252 250 263

256 253 251 243 275

270 260 250 250 277

273 265 263 252 285

276

274

264

268

293

280 277 264 267 305

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met