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EC number: 244-121-9 | CAS number: 20941-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrakis(diethyldithiocarbamato-S,S')tellurium
- EC Number:
- 244-121-9
- EC Name:
- Tetrakis(diethyldithiocarbamato-S,S')tellurium
- Cas Number:
- 20941-65-5
- Molecular formula:
- C20H40N4S8Te
- IUPAC Name:
- N2,N2,N6,N6,N6,N6,N9,N9-octaethyl-1λ³,3,5λ³,5λ³,7,7,8λ³,10-octathia-4λ⁸-telluradispiro[3.3⁴.3⁴.3⁴]trideca-1,5,5,8-tetraene-2,6,6,9-tetramine
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name of the test item (as cited in study report): Tellurium diethyldithiocarbamate
- Batch No.: MT-5D 494
- Appearance: Yellow, powder
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Rabbits, Petersfield, Hampshire, England.
- Weight at study initiation: 2.1-3.1 kg
- Housing: individually in metal cages with perforated floors
- Diet: SQC Standard Rabbit Diet (ad libitum)
- Water: tap water (ad libitum)
- Acclimation period: 10 days
ENVIRONMENT
- Temperature: 20-21 °C
- Humidity: 45%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- 24 hours prior to treatment hair was clipped from the dorso-lumbar region of each rabbit exposing an area approximately 10% of the total body surface area. The test substance was applied by spreading evenly over the clipped treatment site in as uniform a manner as possible moistened with 2.0 ml/kg bodyweight saline. The site was then covered with gauze backed with an occlusive dressing encircled firmly around the trunk of the animal. After the exposure period of 24 hours, the dressing was removed and the treatment site gently washed with water to remove any residual test substance. "Elizabethan" collars were fitted on each rabbit and were worn approximately 23 hours to prevent ingestion of any residual substance.
- Duration of exposure:
- 24 hours
- Doses:
- 2g/kg bodyweight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed soon after dosing and then at frequent intervals for the remainder of Day 1. On subsequent days the animals were observed once in the morning and once at the end of the experimental day. The following were recorded at each observation: approximate time of death of individual rabbits; nature, severity, approximate time of onset and duration of each sign of toxicity. The bodyweight of each rabbit eas recorded on Days 1, 2, 3, 5, 8, 11 and 15 or at death.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female rabbit was found dead on Day 12.
- Clinical signs:
- other: On one occasion during Day 1 (approximately 1.5 hours after dosing) one male and one female rabbit showed an abnormal (unsteady) gait. All other animals appeared normal. Signs of reaction to treatment over the following days included pilo-erection in tw
- Gross pathology:
- Autopsy of the dead female rabbit revealed gaseous filled stomach and intestines. Terminal autopsy revealed a diffuse minimal congestion in the lungs of one male rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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