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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Water solubility:
ca. 1.2 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
10 g/L
Incubation duration:
72 h
Temp.:
20 °C
pH:
6
Water solubility:
0.343 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 g/L
Incubation duration:
72 h
Temp.:
20 °C
pH:
7.3
Water solubility:
ca. 0.085 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.1 g/L
Incubation duration:
72 h
Temp.:
20 °C
pH:
6.2
Conclusions:
The water solubility of the test item at 20.0 ± 0.5 °C has been demonstrated to be loading rate dependent, as shown in the following table:
Nominal Loading Rate (g/L) Concentration (g/L)
0.1 0.0853
1 0.343
10 1.20

As the solubility of the test item was loading rate dependent, a single definitive value was not possible.

Description of key information

The water solubility of the test item at 20.0 ± 0.5 °C has been demonstrated to be loading rate dependent, as shown in the following table:

Nominal Loading Rate (g/L)       Concentration (g/L)       

      0.1                                          0.0853              

      1                                             0.343              

      10                                          1.20              

As the solubility of the test item was loading rate dependent, a single definitive value was not possible.

Key value for chemical safety assessment

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