Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-281-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Toxicity Summary
Acute oral toxicity:
In a recent study (2010), performed according to actual guidelines, an LD50 of >5000 mg/kg bw was determined. The test substance was administered in deionised water. All animals showed signs of reduced well-being fromuntilp. a. This term encompasses unspecific alterations, like sedation, apathy, piloerection, hunched posture or closed eyes, in single or multiple occurrence. There were no other adverse effects noted in the animals.
Acute dermal toxicity:
In a recent study (2010), performed according to actual guidelines, the LD50 was >2000 mg/kg bw and no adverse effects were noted in the animals. No indication for a dermal absorption was obtained from this study.
Repeated dose toxicity:
Results of a Combined Repeated Dose / Reproduction /Developmental Toxicity Screening Study give some indication for an absorption of the test substance in the gastrointestinal tract and a distribution in the body:
In the livers of high dosed males a slight centrolobular hepatocyte cytoplasmatic basophilia was noted. This is interpreted as an indicator of enzyme induction, and is taken as an adaptive response, although not supported by clinical chemistry parameters. A slight proliferation of the limiting ridge of the stomach without signs of inflammation in almost all high dosed males is interpreted as a slight local irritation by the test substance.
All test substance related findings were present only in a low grade of severity and never became life-threatening.
The No-observed-effect-level (NOEL) of the test substance was at 316 mg per kg body weight and day for males and at 870 mg per kg body weight and day for females, based on the effects described above. No severe toxic effects were noted even at a dose of 870 mg/kg.
Reproductive toxicity
In a Combined Repeated Dose / Reproduction /Developmental Toxicity Screening Study (see also above) no effects on reproduction parameters and on the offspring were noted at doses up to 870 mg per kg body weight and day.
Genetic toxicity
The test item gave positive results in one bacterial gene mutation test (positive for three out of five Salmonella strains) and in one in one mammalian cytogenetic study, regardless whether tested without or with the addition of metabolizing enzymes. Both studies were performed under GLP and according to current guidelines. The test item was mutagenic and clastogenic in the two in vitro tests.
Toxicokinetic summary
Absorption / distribution
Absorption of the test substance in the gastrointestinal tract and a distribution in the body was demonstrated by a Combined Repeated Dose / Reproduction /Developmental Toxicity Screening Study with the test item. Indications for systemic effects were also seen after single oral administration (acute oral toxicity).
No systemic effects were noted after single dermal exposure to the test substance (acute dermal toxicity study). The low partition coefficient n-octanol/water (1.67) and the high water solubility (>100 g/L) do not favour a penetration of the test item through biological membranes. The potential for bioaccumulation is considered to be low, based on the low partition coefficient and the ready biodegradability.
Metabolism
No relevant differences occurred in the two mutagenicity studies with and without the addition of a metabolising system. Therefore no indication of the importance of the metabolism of the test item was obtained from these studies.
Excretion
No information is available on excretion of the test item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live2