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Administrative data

Description of key information

LD50 > 3170 mg/kg

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Acute oral toxicity was assessed in rats upon administration of a single oral dose. Doses of 1000, 2150 and 3170 mg/kg were tested and observations were continued up to day 7. No mortality was seen and recovery of dose-related symptoms in terms of sedation, dyspnoea, exophthalmus, curved position and ruffled fur occurred within 6 days.

Justification for classification or non-classification

According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as LD50 (oral, dermal) or LC50 (inhalation) values as well as acute toxicity estimates (ATE).

 

In the available study in rats, oral LD50 value above 2000 mg/kg bw was found. Accordingly, target substance was not classified for acute oral toxicity in the CLP Regulation (EC 1272/2008).

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