Registration Dossier
Registration Dossier
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EC number: 270-220-1 | CAS number: 68413-48-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 February 1981 to 12 February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 16 C.F.R. 1500.41 of the U.S. Federal Hazardous Substances Act Regulations
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate
- EC Number:
- 270-220-1
- EC Name:
- Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate
- Cas Number:
- 68413-48-9
- Molecular formula:
- C28H55O6PS2
- IUPAC Name:
- 1,4-dibutyl 2-({bis[(2-ethylhexyl)oxy](sulfanylidene)-λ⁵-phosphanyl}sulfanyl)butanedioate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Date received: 28 January 1981
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino
- Details on test animals or test system and environmental conditions:
- The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L- 94- 279) 9 CFR Part 3.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Immediately following treatment and 48 hours later.
- Number of animals:
- Six
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: observation period of 48 hours post treatment
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: observation period of 48 hours post treatment
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: observation period of 48 hours post treatment
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material is not a skin irritant.
- Executive summary:
In a study performed according to 16 C.F.R. 1500.41 of the U.S. Federal Hazardous Substances Act Regulations test item has been determined as not classified in relation to skin irritation according to GHS criteria.
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