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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1958
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guideline study, pre-GLP, doses not specified

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report date:
1959

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-ethyl-o(or p)-toluenesulphonamide
EC Number:
232-465-2
EC Name:
N-ethyl-o(or p)-toluenesulphonamide
Cas Number:
8047-99-2
Molecular formula:
C9H13NO2S
IUPAC Name:
N-ethyl-o(or p)-toluenesulphonamide
Test material form:
liquid: viscous
Remarks:
Colour: light yellow
Details on test material:
Ketjenflex 8 (NETSA)
Chemical name in report: N-ethyl-o/p-toluenesulfonamide (or N-substituted toluene sulphonamide)
Description: light yellow viscous liquid
Purity 100% (or 90%)

Test substance storage: at room temperature in the dark
Stability under storage conditions: stable

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Details on inhalation exposure:
Animals were exposed for 3 consecutive days of 8 hours.
No. of animals per sex per dose:
4
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
other: saturated vapours at 177 deg C.
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
None
Clinical signs:
other: Moderate discomfort, slight nasal discharge, inflammation, letargy.

Any other information on results incl. tables

No deaths resulted from the three days exposure. Whitish, aury vapours were given off at a sufficient rate to maintain a moderate inside the chamber. In all probability the atmosfere was kept saturated. Mild discomfort was noted within a few minutes after the start of each days exposure. This developed into moderate lethargy with mild to moderate inflammation of the nasal route. Breating remained about normal. There was moisteming of the nasal passages but only slight discharge. The animals looked normal at the start of each days test and no compications developed during a seven day holding period. The compound becomes dark in colour in one to two hours after being heated. It was comcluded that Santicizer 8 vapours given off at 350 deg F.are moderately irritating in a saturated atmoshere. They were not acutely toxic to rats.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Remarks:
according to the EU classification criteria outlined in Annex I of 1272/2008/EC (CLP)
Conclusions:
No deaths occured in a 3 consecutive day 8 hours exposure of air saturated by Santicizer 8 vapours at 177 deg C .
Executive summary:

Four mature male rats (Sprague-Dawley) were placed in a metal chamber of approximately 35 liters for three consecutive eight hour days to a saturated atmosphere of Sanitizer 8 vapours produced by heating the liquid to 350 deg F (177 deg C). 250 mL of sample was placed in a three hals round bottom flask and the vapours were led into the chamber through a short lenght of hose. A gas burner was used to maintain the proper temperature. Food and water were applied ad lib. Observations were done for behaviour and since there were no deaths, all animals were held for seven days following the test. The average temperature inside the chamber was 76.0 deg F and the average humidity was 58.0%.

No deaths resulted from the three days exposure. Whitish, aury vapours were given off at a sufficient rate to maintain a moderate inside the chamber. In all probability the atmosfere was kept saturated. Mild discomfort was noted within a few minutes after the start of each days exposure. This developed into moderate lethargy with mild to moderate inflammation of the nasal route. Breating remained about normal. There was moisteming of the nasal passages but only slight discharge. The animals looked normal at the start of each days test and no compications developed during a seven day holding period. The compound becomes dark in colour in one to two hours after being heated. It was comcluded that Santicizer 8 vapours given off at 350 deg F.are moderately irritating in a saturated atmoshere. They were not acutely toxic to rats.

As a result, the substance N-Ethyl-o (or p)-toluenesulfonamide (NETSA) does not need to be classified for acute inhalation toxicity according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP).

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