N-ethyl-o(or p)-toluenesulphonamide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1958

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-guideline study, pre-GLP, doses not specified

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1959

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-ethyl-o(or p)-toluenesulphonamide

EC Number:

232-465-2

EC Name:

N-ethyl-o(or p)-toluenesulphonamide

Cas Number:

8047-99-2

Molecular formula:

C9H13NO2S

IUPAC Name:

N-ethyl-4-methylbenzene-1-sulfonamide

Test material form:

liquid: viscous

Remarks:

Colour: light yellow

Details on test material:

Ketjenflex 8 (NETSA)
Chemical name in report: N-ethyl-o/p-toluenesulfonamide (or N-substituted toluene sulphonamide)
Description: light yellow viscous liquid
Purity 100% (or 90%)

Test substance storage: at room temperature in the dark
Stability under storage conditions: stable

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Details on inhalation exposure:

Animals were exposed for 3 consecutive days of 8 hours.

No. of animals per sex per dose:

4

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

other: saturated vapours at 177 deg C.

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

None

Clinical signs:

other: Moderate discomfort, slight nasal discharge, inflammation, letargy.

Any other information on results incl. tables

No deaths resulted from the three days exposure. Whitish, aury vapours were given off at a sufficient rate to maintain a moderate inside the chamber. In all probability the atmosfere was kept saturated. Mild discomfort was noted within a few minutes after the start of each days exposure. This developed into moderate lethargy with mild to moderate inflammation of the nasal route. Breating remained about normal. There was moisteming of the nasal passages but only slight discharge. The animals looked normal at the start of each days test and no compications developed during a seven day holding period. The compound becomes dark in colour in one to two hours after being heated. It was comcluded that Santicizer 8 vapours given off at 350 deg F.are moderately irritating in a saturated atmoshere. They were not acutely toxic to rats.

Applicant's summary and conclusion

Interpretation of results:

other: not classified

Remarks:

according to the EU classification criteria outlined in Annex I of 1272/2008/EC (CLP)

Conclusions:

No deaths occured in a 3 consecutive day 8 hours exposure of air saturated by Santicizer 8 vapours at 177 deg C .

Executive summary:

Four mature male rats (Sprague-Dawley) were placed in a metal chamber of approximately 35 liters for three consecutive eight hour days to a saturated atmosphere of Sanitizer 8 vapours produced by heating the liquid to 350 deg F (177 deg C). 250 mL of sample was placed in a three hals round bottom flask and the vapours were led into the chamber through a short lenght of hose. A gas burner was used to maintain the proper temperature. Food and water were applied ad lib. Observations were done for behaviour and since there were no deaths, all animals were held for seven days following the test. The average temperature inside the chamber was 76.0 deg F and the average humidity was 58.0%.

No deaths resulted from the three days exposure. Whitish, aury vapours were given off at a sufficient rate to maintain a moderate inside the chamber. In all probability the atmosfere was kept saturated. Mild discomfort was noted within a few minutes after the start of each days exposure. This developed into moderate lethargy with mild to moderate inflammation of the nasal route. Breating remained about normal. There was moisteming of the nasal passages but only slight discharge. The animals looked normal at the start of each days test and no compications developed during a seven day holding period. The compound becomes dark in colour in one to two hours after being heated. It was comcluded that Santicizer 8 vapours given off at 350 deg F.are moderately irritating in a saturated atmoshere. They were not acutely toxic to rats.

As a result, the substance N-Ethyl-o (or p)-toluenesulfonamide (NETSA) does not need to be classified for acute inhalation toxicity according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP).