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EC number: 701-216-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Method: other (measured): Monsanto Environmental Sciences method ES-79-M-15: Log Kow of the substance was measured by equilibrating aqueous solutions of radiolabelled compounds with n-octanol. The concentrations of the substance in each phase were determined by Liquid Scintillation Counting (LSC).
- GLP compliance:
- no
- Type of method:
- other: equilibrating aqueous solutions of radiolabelled compounds with n-octanol
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- -3.4
- Remarks on result:
- other: Temperature and pH not stated
- Conclusions:
- A log Kow value of -3.4 was obtained for DTPMP-H using a relevant method. The result is considered to be reliable.
Reference
Test concentration Kow
50 mg/L 4.46 x 10-4
500 mg/L 3.49 x 10-4
Test concentrations are expressed as active acid.
Description of key information
log Kow [DTPMP (5-7Na)]: <-3.4
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.4
Additional information
Log Kow values of -3.4 and -3.5 at 50 mg/L and 500 mg/L test concentrations respectively were reported for the parent acid, DTPMP-H in a reliable study conducted according to generally accepted scientific principles comparable to an appropriate test guideline. The method has been adequately described in the report. The result is considered to be reliable and has been assigned as key study.
DTPMP (5-7Na) is freely soluble in water and, therefore, the DTPMP anion is fully dissociated from its sodium cations when in solution. The DTPMP anion has ten P-OH groups that can be ionised. They lose hydrogen to form a negatively charged group (P-O-). As the pH increases, the number of ionised groups increases. Under any given conditions, the degree of ionisation of the DTPMP species is determined by the pH of the solution. At a specific pH, the degree of ionisation is the same regardless of whether the starting material was DTPMP (4-8K), DTPMP (1-3Na), DTPMP (5-7Na), DTPMP-H, DTPMP (xNH4) or another salt of DTPMP.
Therefore, the log Kow measured for DTPMP-H is directly relevant for DTPMP (5-7Na). The log Kow for an ionising substance will vary with pH as the ionised species will have a greater hydrophilicity and lower log Kow than the neutral species. The pH was not measured in the study with DTPMP-H, however, a solution of DTPMP-H in unbuffered water will have a very low pH. Therefore, the log Kow for DTPMP (5-7Na) is reported as <-3.4.
For further details of the speciation of DTPMP see PFA 2020.
The key study is supported by a calculated log Kow value of -2.8 for DTPMP (5-7Na) using a relevant estimation method.
Reference
PFA 2020: DTPMP speciation at pH relevant to Ecotoxicology and Toxicology, Reference: PFA.224.606.001, May 2020.
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