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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information


The hydrolytic stability of TMEDA (N,N,N’,N’-tetramethylethylenediamine) was determined at pH values normally found in the environment (pH 4-9) via a GLP-compliant test performed according to OECD Guideline 111 (Hydrolysis as a function of pH).


Quantitative analysis of the test item in the study was performed according to a validated analytical method using ultra-performance liquid chromatographic with mass spectrometric detection (UPLC-MS). The test item was spiked to the buffer solutions (pH 4, pH 7 and pH 9) at a target concentration of 2.00 mg/L using a spiking solution in water. Test samples were taken immediately after preparation (t=0) and after 5 days and the concentration of the test item in the test samples was determined.


Results from the preliminary test (Tier 1) showed that at each pH value <10% hydrolysis of the test item was observed after 5 days, thereby demonstrating that the half-life time of the test item at 25°C is >1 year. According to the guideline, performance of the main study (Tier 2) was not required and it is concluded that TMEDA is hydrolytically stable.

Additional information