Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Justification for type of information:
No experimental measurement of vapour pressure was possible as the substance contains water and start to decompose soon after melting.
An estimated value was computed by EPI Suite tool, using SMILE notation as input O=S(O[Zn]OS(=O)c1ccccc1)c2ccccc2 and experimental melting point of 223 °C and water solubility of 887 mg/l.
A low vapour pressure was estimated, i.e. 7E-10 Pa at 25 °C, thus the substance is unlikely available for inhalation as a vapour.

Based on particle size distribution, all particles have a diameter below 100 µm. In general, particles of 10-100 µm size form the inhalable fraction, particles of 4-10 µm size form the thoracic fraction and of 0-4 µm form the respirable fraction. Inhalable and thoracic fractions remain in the high respiratory tract and may be cleared from this region by mucous, cough...; part of these particles become available by oral route upon swallowing. Respirable fraction may enter the deepest part of lungs, namely the non-ciliated alveoli and become systemically available upon absorption. As for test substance, D10 is 5.14 µm, thus respirable fraction is expected to be not significant. Therefore, absorption of test substance via inhalation route possibly resulting in acute toxicity was considered as not likely to occur and inhalation route was considered not relevant for human exposure. On these bases no acute inhalation test was performed.

Data source

Materials and methods

Results and discussion

Clinical signs:
other:

Applicant's summary and conclusion