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EC number: 701-029-8 | CAS number: -
A static test with zebrafish (OECD 203) indicated no mortality at 1000 mg/L after 96 hour.
The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. Two short-term aquatic toxicity studies are available for fish for polymeric MDI (CAS 9016-87-9). In a study with Oryzias latipes (Nakata, 1982), no acute toxicity was observed after 96h exposure to 3000 mg/L (semi-static). ). The Nichi-Nou-Sei B2735 (1965) protocol was followed, which is similar to OECD 203. A static test with Danio rerio (OECD 203) gave no mortality at 1000 mg/L, which was the highest concentration tested (Caspers et al., 1986). This value may be considered for the derivation of a PNECaqua. A third fish study with Danio rerio is available, but lacks some critical information. Hence it is classified as unreliable. The 24h-EC50 was determined to be > 500 mg/L. Based on the justification in the category approach of methylenediphenyl diisocyanates (MDI), it is assumed that all MDI analogues included in the category have a similar fish toxicity.
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