Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to EU risk assessment report, Cas No. 26447-40-5, methylenediphenyl diisocyanate (MDI), volume 59 (public available peer reviewed source)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report date:
1994

Materials and methods

Study type:
clinical case study
Endpoint addressed:
eye irritation
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-methylenediphenyl diisocyanate
EC Number:
202-966-0
EC Name:
4,4'-methylenediphenyl diisocyanate
Cas Number:
101-68-8
Molecular formula:
C15H10N2O2
IUPAC Name:
1,1'-methylenebis(4-isocyanatobenzene)
Constituent 2
Reference substance name:
benzene, 1,1'- methylenebis[4-isocyanato-
IUPAC Name:
benzene, 1,1'- methylenebis[4-isocyanato-
Details on test material:
- Name of test material (as cited in study report): 4,4'-MDI (Rock glue)
- Analytical purity: not reported

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: no data
Route of exposure:
ocular
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Results of examinations:
symptoms of eye irritation were reported.

Applicant's summary and conclusion