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EC number: 810-260-4
CAS number: 1115251-57-4
a reverse gene mutation assay performed according to the OECD test
guideline No. 471 and in compliance with GLP, S. typhimurium strains TA
98, TA 100, TA 102 and TA 1535 and E. coli WP2(pKM101) were exposed to PI
2080 diluted in ethanol both in the presence and absence of metabolic
activation system (10% liver S9 in standard co-factors) using the plate
incorporation method. In a preliminary toxicity assay, citotoxicity was
assessed between 0.06 and 5 mg/plate on TA100. The lowest cytotoxic
concentration was 5 mg/plate, used as the highest concentration in the
test item formulation for the two main experiments. In the second experiment,
preincubation was added to the experimental procedure.
vehicle (ethanol) control plates gave counts of revertant colonies
within the normal range. All of the positive control chemicals used in
the test induced marked increases in the frequency of revertant
colonies, both with or without metabolic activation.
significant increases in the frequency of revertant colonies were
recorded for any of the bacterial strains, at any dose level either with
or without metabolic activation.
In these experimental conditions, PI 2080
was not mutagenic with and without metabolic activation in S.
thyphimurium strains TA 98, TA 100, TA 1535 and TA 1537 and E. coli
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