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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06-03-2018 to 06-04-2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Water solubility:
164 mg/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
4.2
Remarks on result:
other: stirred at 20 ± 0.2 °C
Water solubility:
152 mg/L
Conc. based on:
test mat.
Incubation duration:
49 h
Temp.:
20 °C
pH:
4.2
Remarks on result:
other: stirred at 20 ± 0.2 °C
Water solubility:
144 mg/L
Conc. based on:
test mat.
Incubation duration:
73 h
Temp.:
20 °C
pH:
4.4
Remarks on result:
other: stirred at 20 ± 0.2 °C
Water solubility:
154 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: mean of 24, 49 and 73 hours
Details on results:
Water solubility calculated as the mean value of the 24, 49- and 73-hour measurements:
mean water solubility = 0.154 g/L or 154 mg/L

Preliminary test:

Test 1: water solubility = 179 mg/L

 

Definitive test:

The water solubility of the test item was given as the mean value of the 24, 49 - and 73 -hour measurements as there was less than 15 % maximum difference in the samples. No test item was detected in the pre-treated sample from the blank water mixture.

Conclusions:
Interpretation of results: moderately soluble (100-1000 mg/L)
The test item water solubility was determined to be 154 mg/L of solution at 20.0 °C.
Executive summary:

The water solubility of the test item was determined according to the flask method of OECD TG 105, EU Method A.6 and US EPA OPPTS 830.7840 in accordance with GLP. The solubility of the test item in double distilled water was determined employing the flask method at 20 ± 0.5 °C with incubation at test temperature for 24, 49 and 73 h. The analytical method (UPLC-TUV, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The mean water solubility of the test item was determined to be 154 mg/L at pH 4.4 and 20 °C.

Description of key information

Water Solubility: 154 mg/L at 20 °C, OECD TG 105 - flask method, 2018

Key value for chemical safety assessment

Water solubility:
154 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined according to the flask method of OECD TG 105, EU Method A.6 and US EPA OPPTS 830.7840 in accordance with GLP. The solubility of the test item in double distilled water was determined employing the flask method at 20 ± 0.5 °C with incubation at test temperature for 24, 49 and 73 h. The analytical method (UPLC-TUV, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The mean water solubility of the test item was determined to be 154 mg/L at pH 4.4 and 20 °C.