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EC number: 300-496-1 | CAS number: 93940-97-7
Acute toxicity to fish
Experimental data on the acute toxicity of modified Isophoronediamine (CAS 93940-97-7) towards fish are not available.However, several (Q)SAR models were used in order to assess the acute toxicity to fish. All QSAR models applied calculated 96-h LC50 values between >10 mg/L and <= 100 mg/L; the substance was within the applicability domain of all models. The lowest calculated value of 53.1 mg/L is considered for the assessment (worst-case approach). Based on the calculated data, the substance is concluded to be acutely harmful to fish.
Acute toxicity to invertebrates
The acute toxicity of modified Isophoronediamine (MIPDA, CAS 93940 -97 -7) to aquatic invertebrates (Daphnia magna) was investigated in a 48 -hour static GLP-test according ot OECD 202 (BASF SE 2005, report no. 50EO405/053125). The 48 -h EC50 was determined to be 51.9 mg/L based on nominal concentrations, which were analytically verified. The pH of the test solutions was not adjusted. The test is valid according to OECD criteria.
Therefore, the substance is concluded to be acutely harmful to aquatic invertebrates.
Toxicity to algae and cyanobacteria
The effects of modified Isophoronediamine (MIPDA, CAS 93940 -97 -7) on fresh water algae have been assessed using data from a growth inhibition test according to OECD 201 with the algal species Desmodesmus subspicatus (BASF SE 2013, report no. 60E0241/13X030). Algae were exposed to the following nominal concentrations for 72 h: 4.6, 10, 22, 46 and 100 mg/l. The initial and final concentrations of MIPDA were maintained within the designated limit of 80% of the nominal concentrations. Therefore, the effect concentrations have been calculated using the nominal concentrations. The validity criteria of the study were fulfilled. The 72h-ErC50 was determined to be > 100 mg/L and the 72h-ErC10 was 37 mg/L.
It is concluded that the substance is with high probability acutely not harmful to algae and cyanobacteria.
Toxicity to aquatic microorganisms
A GLP test according to OECD 209 was performed with modified Isophoronediamine (BASF SE 2005, report no. 08G0405/053154). As inoculum actived sludge from a municipal wastewater plant in Mannheim/Germany was used, the pH of the test solutions was adjusted. The EC20 after 180 min was determined to be 450 mg/L (BASF SE, 2005). The test is valid according to OECD criteria.
It is concluded, the inhibition of the degradation activity of activated sludge is not anticipated when the substance is introduced in appropriately low concentrations.
Long-term toxicity to fish / aquatic invertebrates
Not required under REACH
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