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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
April 16, 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The model is been assessed according to the OECD principles for the validation of QSAR, to generate a transparent, understandable, reproducible and verifiable result.

Data source

Reference
Reference Type:
review article or handbook
Title:
QSAR Application Toolbox Workflow
Author:
Laboratory of Mathematical Chemistry, Bourgas University “Prof. Assen Zlatarov”, Bulgaria
Year:
2017
Bibliographic source:
https://www.qsartoolbox.org/documents/21638082/21638271/1_qsar_toolbox_4_general_presentation_en.pdf

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Version / remarks:
ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
Prediction was calculated using QSAR Toolbox v.4.2 Database version: 4.2

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethyl benzene-1,2,4-tricarboxylate
EC Number:
219-547-3
EC Name:
Trimethyl benzene-1,2,4-tricarboxylate
Cas Number:
2459-10-1
Molecular formula:
C12H12O6
IUPAC Name:
trimethyl benzene-1,2,4-tricarboxylate

Test animals

Species:
rabbit

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
2 460 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute dermal median lethal dose (LD50) in the rabbit was determined to be 2460 mg/kg bw
Executive summary:

The acute dermal median lethal dose (LD50) in the rabbit was determined to be 2460 mg/kg bw