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EC number: 219-547-3
CAS number: 2459-10-1
Skin sensitisation: Not sensitising
Test item concentration
Mean DPM per animal (2 lymph nodes)a)
Vehicle Control Group (DMF)
DPM/animal was determined by dividing the sum of the measured values
from lymph nodes of all
within a group by the number of animals in that group (5 animals)
The EC3 value could not be calculated, since all S.I.´s are below the
threshold value of 3.
No deaths occurred during the study period.
No signs of systemic toxicity or any signs of local skin irritation were
observed during the study period.
The body weight of the animals, recorded prior to the first application
and prior to treatment with 3HTdR, was within the range
commonly recorded for animals of this strain and age.
The measured lymph node weights and –cell counts of all animals treated
were recorded after sacrifice. A statistically significant or
biologically relevant increase in lymph node weights or – cell counts
was not observed in any of the test item treated groups in comparison to
the vehicle control group. For BALB/c mice, a cut-off value for the
lymph node cell count index of 1.55 was reported for a positive
response. The indices determined for the lymph node cell count did not
exceed this threshold.
The measured ear weight of all animals treated was recorded on test day
6 (after necropsy). A biologically relevant or statistically significant
increase in ear weights was not observed. Furthermore, the cut-off value
(1.1) of the ear weight index for a positive response regarding ear skin
irritation reported for BALB/c mice was not exceeded in any of the
the results of the available data the substance does not require to be
classified and labelled according to Regulation 1272/2008/EC (CLP) or
Directive 67/548/EEC (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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