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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
data published in 1941
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
publication
Title:
Hydrogen Bonding and the Solubility of Alcohols and Amines in Organic Solvents
Author:
Copley M.J., Ginsberg E., Zellhoefer G.F., Marvel C.S.
Year:
1941
Bibliographic source:
Journal of the American Chemical Society, 63, 254-256, 1941

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: The "ideal" or theoritical mole fraction solubility was calculated using Raoult's law. It is the ration of the vapor pressure of the solute at 4.5°C to its value at 32.2°C.
- Short description of test conditions: The method used in making the solubility measurements is the sames as previously described by Zellhoefer G.F. et al., Ind. Eng. Chem., 29, 548-551 (1937). Solubility measurements were made over a range of pressures at a temperature of 32.2°C. For comparative purposes, the solubitiy at a partial pressure cooresponding to the vapor pressure of the solute at 4.5°C wer ealso determined.
- Parameters analysed / observed:. Vapour pressure at 32.2°C and 4.5°C to determine solubility of the test compound in organic solvents.
GLP compliance:
no

Test material

Specific details on test material used for the study:
The test substance was purified carefully by chemical mean and chemical distillation.

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
other: ethylene glycol
Solubility:
0.227 other: mole fraction
Temp.:
4.5 °C
Remarks on result:
other: theoritical mole fraction solubility
Remarks:
calculated using Raoult's law
Medium:
other: ethylene gylcol
Solubility:
0.381 other: mole fraction
Temp.:
4.5 °C
Remarks on result:
other: observed mole fraction solubility
Test substance stable:
not determined

Any other information on results incl. tables

Vapor pressure of the test substance at 4.5°C: 45.4 mm.

Vapor pressure of the test substance at 32.2°C: 199 mm.

Applicant's summary and conclusion

Conclusions:
TThe theoritical mole fraction solubility is of 0.227 as the measured one is of 0.381 in ethylene glycol. This study did not followed any guideline and lacks a lot of information regarding the experimental procedure such as temperature effects, information on chemical stability. It was considered to not be reliable.
Executive summary:

The theoritical mole fraction solubility was calculated using Raoult's law, and is the ratio of the vapor pressure of the test substance at 4.5°C to its value 32.2°C. Additionnally, the solubility of the test substance was measured at 4.5°C using a method previously described By Zellhoefer G.F., Ind. Eng. Chem., 29, 548 -551 (1937). The theoritical mole fraction solubility is of 0.227 as the measured one is of 0.381 in ethylene glycol. This study did not followed any guideline and lacks a lot of information regarding the experimental procedure such as temperature effects, information on chemical stability. It was considered to not be reliable.