Registration Dossier
Registration Dossier
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EC number: 946-283-2 | CAS number: 1864727-96-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 24 August, 2017 to 27 November, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- (cyclohex-3-en-1-yl)methyl 2-hydroxypropanoate
- EC Number:
- 946-283-2
- Cas Number:
- 1864727-96-7
- Molecular formula:
- C10H16O3
- IUPAC Name:
- (cyclohex-3-en-1-yl)methyl 2-hydroxypropanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 9 week-old at dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 300 and 2000 mg/kg
- No. of animals per sex per dose:
- three
- Control animals:
- no
- Details on study design:
- The dose level was set at 300 mg/kg for experiment 1 and 2 and 2000 mg/kg for experiment 3 and 4. Three females were used in each experiment. Clinical observation and body weight measurement were conducted after administration and necropsy was performed after the completion of a 14-day observation period.
- Statistics:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: Decrease in locomotor activity was transiently noted after dosing in experiment 3 and 4.
- Gross pathology:
- No macroscopic change was noted in any animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, the test substance has a LD50 above 2000 mg/kg bw and therefore is not classified according to the GHS criterias.
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