Phosphoric acid, ethyl ester

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1964-01-08

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl dihydrogen phosphate

EC Number:

216-603-9

EC Name:

Ethyl dihydrogen phosphate

Cas Number:

1623-14-9

Molecular formula:

C2H7O4P

IUPAC Name:

Phosphoric acid,monoethyl ester

Test material form:

liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

2, 3.2, 5 and 8 g/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

4 300 mg/kg bw

Based on:

test mat.

Mortality:

2 g/kg: 0/10
3.2 g/kg: 1/10
5 g/kg: 6/10
8 g/kg: 10/10

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 of Phosphoric acid, ethylester was estimated as 4300 mg/kg bw.

Executive summary:

The acute oral LD50 of Phosphoric acid, ethylester was estimated as 4300 mg/kg bw.