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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-02-16 to 2018-05-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
no
Type of method:
effusion method: vapour pressure balance
Temp.:
20 °C
Vapour pressure:
0.33 Pa
Temp.:
25 °C
Vapour pressure:
0.56 Pa
Temp.:
50 °C
Vapour pressure:
5.6 Pa

The vapour pressure was measured in the temperature range of 10 °C to 40 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1. The mass of test item was determined before (1.2274 g) and after (0.0037 g) the vapour pressure measurement. A mass loss of approx. 100% (w/w) was observed.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C

Vapour pressure / hPa

10

1.3 × 10-3

15

1.7 × 10-3

20

3.1 × 10-3

25

5.7 × 10-3

30

9.9 × 10-3

35

1.6 × 10-2

40

2.2 × 10-2

30

n.e.

n.e.: not evaluable, measuring cell nearly empty

From the measured data the parameters A, B and C of the Antoine equation can be derived by regression. The vapour pressure values for 20, 25, and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C) using the Antoine constants.

Conclusions:
The vapour pressure of the test item was determined according to OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 10 °C to 40 °C. The vapour pressure values for 20, 25, and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C) using the Antoine constants.
20 °C: 0.33 Pa;
25 °C: 0.56 Pa;
50 °C: 5.6 Pa.
Executive summary:

The vapour pressure of the test item was determined according to OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 10 °C to 40 °C. The vapour pressure values for 20, 25, and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C) using the Antoine constants.

20 °C: 0.33 Pa;

25 °C: 0.56 Pa;

50 °C: 5.6 Pa.

Description of key information

The vapour pressure of the test item was determined according to OECD guideline 104 by effusion method using a vapour pressure balance.

20 °C: 0.33 Pa;

25 °C: 0.56 Pa;

50 °C: 5.6 Pa.

Key value for chemical safety assessment

Vapour pressure:
0.56 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure was measured in the temperature range of 10 °C to 40 °C. The vapour pressure values for 20, 25 and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C) using the Antoine constants.