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Toxicity to aquatic algae and cyanobacteria

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toxicity to aquatic algae and cyanobacteria
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
toxicity to aquatic algae and cyanobacteria
Type of information:
other: Secondary literature
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is listed in the Pesticide Ecotoxicity Database from the EPA and thus considered as a reliable study.
Justification for type of information:
The information is available on the US EPA Homepage (CAS #/Chemical: 643798 - 1,2-Benzenedicarboxaldehyde). However, original reports cannot be accessed.
according to guideline
EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II) (January 2012)
not specified
GLP compliance:
not specified
Specific details on test material used for the study:
1,2-Benzenedicarboxaldehyde (Ucarcide P200), 98.0 % purity
Analytical monitoring:
not specified
not specified
Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Test type:
Water media type:
Limit test:
Total exposure duration:
4 d
Reference substance (positive control):
not specified
Key result
4 d
Dose descriptor:
Effect conc.:
184 µg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: Abundance
Validity criteria fulfilled:
not specified
A 96-h EC50 for ortho-phthalaldehyde towards Pseudokirchneriella subcapitata is reported with 184 µg/L (95 % C.I. = 171–200 µg/L).
Executive summary:

The presented information is reported on the EPA database ECOTOX Knowledgebase - ECOTOX: Aquatic report:

In a 96-hour acute toxicity study, the cultures of Pseudokirchneriella subcapitata were exposed to ortho-phthalaldehyde. The range of concentrations is not reported in the secondary source. The test design was static and in accordance with the OPPTS 850.5400 guideline. The EC50 value based on abundance is 184 µg/L.

Further information is not available on the EPA homepage and the access to the original study is not possible. Therefore, the results from this toxicity study are classified as supplementary information.

Results synopsis

Test organism: Pseudokirchneriella subcapitata

Test type: Static

96-hr EC50: 184 µg a.i./L (95 % C.I. = 171–200 µg/L

Endpoint(s) effected: Abundance

Description of key information

The short-term toxicity testing on Daphnia magna showed that the most rigorous classification is necessary for the test item, i.e. Aquatic Acute 1 (H400) and Aquatic Chronic 1 (H410) following the provisions laid down in the CLP Regulation (Regulation (EC) No 1272/2008). Therefore, further testing would not contribute to additional benefit of scientific knowledge.

Key value for chemical safety assessment

EC50 for freshwater algae:
184 µg/L

Additional information

Effect values on Pseudokirchneriella subcapitata are available on the EPA homepage and reported as supplementary data. As the original study is not accessible the data published on the EPA homepage are reported in the present dossier.

In a static growth-inhibition study, algae were exposed for 96 hours to the test substance. An EC50 of 184 µg/L was determined.