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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the Safety Assessment of Tocopherol, TocopherylAcetate, TocopherylLinoleate, TocopherylLinoleate/Oleate, TocopherylNicotinate, TocopherylSuccinate, DioleylTocopherylMethylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, Tocophersolan
Author:
Monice Zondlo Fiume
Year:
2002
Bibliographic source:
International Journal of Toxicology, 21 (Suppl. 3): 51-116, 2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
α-tocopherol
EC Number:
200-412-2
EC Name:
α-tocopherol
Cas Number:
59-02-9
Molecular formula:
C29H50O2
IUPAC Name:
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
Test material form:
liquid: viscous

Test animals

Species:
rat
Details on test animals or test system and environmental conditions:
Details not provided.

Administration / exposure

Route of administration:
oral: unspecified
Details on oral exposure:
Details not provided.
Doses:
4000 mg/kg bw
Details on study design:
Details not provided.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 4 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The oral LD50 of Tocopherol was stated as > 4 g/kg for rats.