Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-847-9 | CAS number: 53894-23-8
Four groups of four New Zealand White rabbits (identified as males and females, but not with specified distribution) were exposured to 50, 200, 794, and 3160 mg/kg body weight of the test substance on abraded skin for 24 hours under occlusive conditions. Observations of the skin condition were made at 24 hours and daily thereafter for up to 14 days. Mild erythema was noted in all exposed animals at the first examination (24 hour time point), but did not increase in severity or duration with dose. All signs of skin irritation were resolved within six days. The results indicate that exposure to the test substance under conditions more extreme than current guidelines produced mild skins of skin irritation which were fully reversed during the observation period. On that basis the substance does not meet criteria for classification as a skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again