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EC number: 265-409-0 | CAS number: 65104-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- In vitro study not performed since in vivo study available.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 15 1978-December 15 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Justification for type of information:
- In vitro study not performed since in vivo study available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The irritation test was conducted on ten unexposed guinea pigs by applying and lightly rubbing in 0.05 ml of a 25% solution of test material in water on shaved and intact shoulder skin. Reactions on skin were investigated after 24 h and 48 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diammonium dihydroxybis[lactato(2-)-O1,O2]titanate(2-)
- EC Number:
- 265-409-0
- EC Name:
- Diammonium dihydroxybis[lactato(2-)-O1,O2]titanate(2-)
- Cas Number:
- 65104-06-5
- Molecular formula:
- C6H18N2O8Ti
- IUPAC Name:
- Diammonium dihydroxybis[lactato(2-)-O1,O2]titanate(2-)
- Test material form:
- solid: particulate/powder
1
- Specific details on test material used for the study:
- 25% solution of test material in water
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Remarks:
- albino
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.05 ml of 25% test material
- Duration of treatment / exposure:
- 24 h and 48 h
- Number of animals:
- 10
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal: #10
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal: #9
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal: #8
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal: #7
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal: #10
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal: #9
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal: #8
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal: #7
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Remarks:
- Observations were recorded only at 24h and 48h timepoints.
- Irritant / corrosive response data:
- Mild erythema was observed in 50% of animals after 24 and 20% of animals after 48 h exposure to test item.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test material is skin irritant as 25% in water.
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