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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Neurotoxicity

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Administrative data

Endpoint:
neurotoxicity: oral
Remarks:
developmental
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Effects of prenatal aluminum treatment on development and behavior in the rat
Author:
Misawa, T. and Shigeta, S.
Year:
1993
Bibliographic source:
The Journal of Toxicological Sciences 18: 43-48

Materials and methods

Principles of method if other than guideline:
Developmental and behavioral effects of aluminum administration were studied in THA rats.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Aluminium chloride
EC Number:
231-208-1
EC Name:
Aluminium chloride
Cas Number:
7446-70-0
IUPAC Name:
aluminum trichloride
Details on test material:
- Name of test material (as cited in study report): Aluminum chloride, Wako Chemical Co., Japan
- Analytical purity: 98.0%

Test animals

Species:
rat
Strain:
other: THA
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
physiological saline
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
single dose
Frequency of treatment:
single treatment
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 900, 1800 mg/kg AlCl3
Basis:
nominal conc.
No. of animals per sex per dose:
3-4
Control animals:
yes, concurrent vehicle

Results and discussion

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
900 mg/kg bw/day (nominal)
Sex:
female
Remarks on result:
other: Generation: maternal (migrated information)
Dose descriptor:
LOAEL
Effect level:
900 mg/kg bw/day (nominal)
Sex:
male/female
Basis for effect level:
other: significant differences in body weight, timing of pinna detachment, eye opening, appearances of auditory startle, slower learning acquisition compared to controls
Remarks on result:
other: Generation: offspring (migrated information)

Any other information on results incl. tables

Dam data:

Two of three dams in the high dose group died immediately after administration. These dams were examined by autopsy without relevant findings. No significant difference in the body weight gain from the conception to parturition and other toxic signs by macroscopic examination were observed among the all survived groups. All survived dams delivered. No differences in the mean number of implantation sites, birth rate, mean litter size and maternal behaviors were observed among the three groups of rats.

Pup data:

Body weights of treatment rats were commonly lower than controls from birth to 28th day and significant differences were present between control and treatment groups.

Significant differences were observed between the aluminum treated offspring and controls in terms of body weight, timing of pinna detachment and eye opening, and appearnces of auditory startle. Slower learning acquisition was observed in 1800 mg/kg treated females.

These results suggest that single dose of aluminum chloride during prenatal period affects the development and behavior in rats.

Applicant's summary and conclusion

Conclusions:
Results from the present study indicated low avoidance rates during the initial stages of the test and apparent delay in learning acquisition among aluminum treated rats. This study was designed to clarify the developmental and behavioral effects of single dose of aluminum treatment during prenatalperiod in rats. The results suggest that the effects of single dose of 900 mg/kg and 1800 mg/kg aluminum administration on 15th day of gestation can induce long-term effects on the central nervous system.