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Administrative data

sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Report in secondary literature (peer reviewed)

Data source

Reference Type:
secondary source
Habs, H. et al.
Bibliographic source:

Materials and methods

Study type:
case report
GLP compliance:
not specified

Results and discussion

Applicant's summary and conclusion

Executive summary:

Although human exposure to aluminium is widespread, hypersensitivity has been

reported following exposure to some aluminium compounds in only a few cases, either after dermal application or parenteral administration. A case of contact sensitivity to aluminium was reported in Sweden. The patient had regularly been using an aluminium chloride roll-on antiperspirant and developed an itchy dermatitis in the axillae. Patch-tests with aluminium chloride were positive. Contact allergy to aluminium also occurred in a patient hyposensitized with aluminium-precipitated grass pollen. Two cases of contact allergy to aluminium after use of topical medications containing aluminium acetotartrate have been reported. Childhood immunization with an aluminium-bound vaccine can lead to delayed hypersensitivity to aluminium. Children who had had previous injections with these vaccines showed positive patch-tests to aluminium chloride. In Denmark a follow-up study was made of 202 children (age 6-15 years) who had received hyposensitization therapy with various aluminium-containing extracts (subcutaneous application) for an average of 3 years. One to three years after cessation of hyposensitization, 4% (13 children) still had severely pruriginous treatment-resistant subcutaneous nodules in their forearm (application site). Six of these 13 children were patch-tested and four reacted positively on aluminium chloride administration.