Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-289-2 | CAS number: -
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report in secondary literature (peer reviewed)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- ENVIRONMENTAL HEALTH CRITERIA 194 - Aluminium
- Author:
- Habs, H. et al.
- Year:
- 1 997
- Bibliographic source:
- http://www.inchem.org/documents/ehc/ehc/ehc194.htm
Materials and methods
- Study type:
- case report
- GLP compliance:
- not specified
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Although human exposure to aluminium is widespread, hypersensitivity has been
reported following exposure to some aluminium compounds in only a few cases, either after dermal application or parenteral administration. A case of contact sensitivity to aluminium was reported in Sweden. The patient had regularly been using an aluminium chloride roll-on antiperspirant and developed an itchy dermatitis in the axillae. Patch-tests with aluminium chloride were positive. Contact allergy to aluminium also occurred in a patient hyposensitized with aluminium-precipitated grass pollen. Two cases of contact allergy to aluminium after use of topical medications containing aluminium acetotartrate have been reported. Childhood immunization with an aluminium-bound vaccine can lead to delayed hypersensitivity to aluminium. Children who had had previous injections with these vaccines showed positive patch-tests to aluminium chloride. In Denmark a follow-up study was made of 202 children (age 6-15 years) who had received hyposensitization therapy with various aluminium-containing extracts (subcutaneous application) for an average of 3 years. One to three years after cessation of hyposensitization, 4% (13 children) still had severely pruriginous treatment-resistant subcutaneous nodules in their forearm (application site). Six of these 13 children were patch-tested and four reacted positively on aluminium chloride administration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
