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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available

Data source

Reference
Reference Type:
publication
Title:
Skin Absorption and Hippocampal Bioaccumulation of Water Soluble Aluminium Chloride in Mice
Author:
Anane, R. et al.
Year:
1995
Bibliographic source:
Human & Experimental Toxicology

Materials and methods

Objective of study:
absorption
Principles of method if other than guideline:
Aluminium skin absorption was investigated in mice.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Aluminium chloride
EC Number:
231-208-1
EC Name:
Aluminium chloride
Cas Number:
7446-70-0
IUPAC Name:
aluminum trichloride
Details on test material:
- Name of test material (as cited in study report): aluminium chloride
- Analytical purity: no data
Radiolabelling:
no

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: percutaneous
Vehicle:
not specified
Duration and frequency of treatment / exposure:
ervery day for 130 days
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 and 0.4 μg
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Skin exposure to aluminium chloride produced a significant increase (p<0.05) of aluminium accumulation in the brain, especially in the hippocampal area. This finding was confirmed by microanalysis on slices of hippocampus showing accumulation of aluminium silicates.
Details on distribution in tissues:
not determined
Details on excretion:
not determined

Metabolite characterisation studies

Metabolites identified:
not measured

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): high bioaccumulation potential based on study results