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EC number: 429-280-6 | CAS number: 151900-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Assessment of toxicokinetic behaviour
- Type of information:
- other: Assessment of toxicokinetic behaviour
- Adequacy of study:
- key study
- Reliability:
- other: Assessment of toxicokinetic behaviour
- Rationale for reliability incl. deficiencies:
- other: other: Assessment of toxicokinetic behaviour
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- Objective of study:
- other: Assessment of toxicokinetic behaviour
- Principles of method if other than guideline:
- Assessment of toxicokinetic behaviour
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 429-280-6
- EC Name:
- -
- Cas Number:
- 151900-44-6
- Molecular formula:
- Hill formula: C36H40N2S6 CAS formula: C36H40N2S6
- IUPAC Name:
- N,N-dibenzyl({6-[(dibenzylcarbamothioyl)disulfanyl]hexyl}disulfanyl)carbothioamide
- Details on test material:
- Assessment of toxicokinetic behaviour
Constituent 1
Results and discussion
- Preliminary studies:
- There are no study data available for the toxicokinetic of the test substance Vulcuren VP KA 9188.
The test substance Vulcuren VP KA 9188 has a solid state under normal condition. The calculated vapor pressure is about 3.9E-18 Pa (20°C) and thus an exposure to the inhalation route could be practically excluded.
The physical and chemical properties (like water solubility < 0.05 mg/l at 25°C, log Pow: 10.4 at 20°C) as well as the molecule size (mol weight: 693.12) let to the conclusion that the oral and dermal resorption rate is low.
This assumption is in line by the available data from acute oral and acute dermal studies (Hüls AG 1992a, Hüls AG 1992b). After a single oral or dermal application of the test substance (2000 mg/kg bw) to male or female rats only transient and weak clinical symptoms and no mortality were seen. On the other hand, no mortality was observed in the in vivo micronucleus assay with male rats, which were treated ip. with up to 4000 mg/kg test substance (twice, 24 h interval) (Bayer 2000c). The bypass of the absorption barrier of the gastrointestinal tract or the skin and thus a presumably higher systemic availability from the test substance, no mortality was seen. This could be evidence that the test substance has a very low intrinsic toxic potential.
In a subacute toxicity study with Wistar rats (Bayer AG 2000f), which were treated per gavage with 0, 40, 200 and 1000 mg/kg bw and day, no substance-related toxicity was observed. Thus, even with a log Pow of 10.4 there is no evidence of appreciable cumulative potential of the test substance. Based on data from the clinical chemistry, gross pathology and histopathology, as well as the evaluation of the excrements, no conclusion of the main elimination ways could be drawn.
The results from the in vitro chromosome aberration assay (Bayer 2000b) showed an increase in cytotoxicity in presence of metabolic activation (S9-mix). Thus, it could be concluded, that the test substance Vulcuren VP KA 9188 could be metabolized by microsome enzymes of the rat liver; whereas the metabolite is more reactive than Vulcuren VP KA 9188. The weak positive effect in the in vitro chromosome aberration assay indicated the induction of DNA-reactive metabolites. However the negative results in the in vivo micronucleus assay (Bayer AG 2000e) and in vivo comet assay (Lanxess GmbH 2005) indicated that in mammalians no appreciable amounts of these DNA-reactive metabolites are generated.
Any other information on results incl. tables
Assessment of toxicokinetic behaviour
Applicant's summary and conclusion
- Executive summary:
There are no study data available for the toxicokinetic of the test substance Vulcuren VP KA 9188.
The test substance Vulcuren VP KA 9188 has a solid state under normal condition. The calculated vapor pressure is about 3.9E-18 Pa (20°C) and thus an exposure to the inhalation route could be practically excluded.
The physical and chemical properties (like water solubility < 0.05 mg/l at 25°C, log Pow: 10.4 at 20°C) as well as the molecule size (mol weight: 693.12) let to the conclusion that the oral and dermal resorption rate is low.
This assumption is in line by the available data from acute oral and acute dermal studies (Hüls AG 1992a, Hüls AG 1992b). After a single oral or dermal application of the test substance (2000 mg/kg bw) to male or female rats only transient and weak clinical symptoms and no mortality were seen. On the other hand, no mortality was observed in the in vivo micronucleus assay with male rats, which were treated ip. with up to 4000 mg/kg test substance (twice, 24 h interval) (Bayer 2000c). The bypass of the absorption barrier of the gastrointestinal tract or the skin and thus a presumably higher systemic availability from the test substance, no mortality was seen. This could be evidence that the test substance has a very low intrinsic toxic potential.
In a subacute toxicity study with Wistar rats (Bayer AG 2000f), which were treated per gavage with 0, 40, 200 and 1000 mg/kg bw and day, no substance-related toxicity was observed. Thus, even with a log Pow of 10.4 there is no evidence of appreciable cumulative potential of the test substance. Based on data from the clinical chemistry, gross pathology and histopathology, as well as the evaluation of the excrements, no conclusion of the main elimination ways could be drawn.
The results from the in vitro chromosome aberration assay (Bayer 2000b) showed an increase in cytotoxicity in presence of metabolic activation (S9-mix). Thus, it could be concluded, that the test substance Vulcuren VP KA 9188 could be metabolized by microsome enzymes of the rat liver; whereas the metabolite is more reactive than Vulcuren VP KA 9188. The weak positive effect in the in vitro chromosome aberration assay indicated the induction of DNA-reactive metabolites. However the negative results in the in vivo micronucleus assay (Bayer AG 2000e) and in vivo comet assay (Lanxess GmbH 2005) indicated that in mammalians no appreciable amounts of these DNA-reactive metabolites are generated.
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