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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10-1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study done under GLP and complete
Qualifier:
according to guideline
Guideline:
other: OECD 202 and EU C.2 of 92/69/EEC
GLP compliance:
yes
Analytical monitoring:
yes
Vehicle:
yes
Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: Acetone
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h
Hardness:
CA 100 mg CaCO3/L
Test temperature:
21 C
pH:
7.7
Dissolved oxygen:
7.6-8.1 mg/L
Nominal and measured concentrations:
nominal 2 mg/L
Reference substance (positive control):
no
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
> 2 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 2 mg/L
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 2 mg/L
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 2 mg/L
Details on results:
%Concentration loss over test: 16 ...
Validity criteria fulfilled:
yes
Conclusions:
study is valid and complete, therefore the EC50 is determined to be > 2 mg/L

Description of key information

The results of an OECD 202 GLP study show that substance is not acutely toxic to Daphnia at maximum soluble concentration.

Key value for chemical safety assessment

Additional information

Three OECD 202 GLP studies are available, with one as a supporting study with no analytics and the second one where no analysis was performed and the content of the test concentration is unknown. The third test conducted in 1997 is chosen as the key study, as it meets all the requirements of a valid study. Under the conditions of the test the EC50 (48h) could not be determined and may only be expressed as > the maximum water solubility in the test.