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EC number: 214-022-5 | CAS number: 1073-05-8
In this guideline (OECD 201) study conducted with GLP certification, the objective of this study was to evaluate the toxicity of 1,3,2-Dioxathiane, 2,2-dioxide on alga Pseudokirchneriella subcapitata. A range-finding test was conducted to find the concentrations that cause algae growth inhibition. Based on the results of the range-finding test, a definitive test was carried out with the following concentrations of test substance: 0 (control); 1; 3.2; 10; 32 and 100 mg.L-1. The test was incubated during 72 hours inside chambers with controlled conditions of luminosity, temperature, and agitation. The 72-hours EyC50(yield) value was 10,44 mg/L and the 72-hours ErC50(growth rate) value was 84,64 mg/L. The highest test substance concentration which no observed significant adverse effect (NOEC) on algal growth was 1 mg/L and the lowest test substance concentration at which was observed significant reducing effect on growth (LOEC) was 3.2 mg/L.
Study carried out according to guideline and with GLP compliance.
The key study for the determination of the inhibition of algal growth was conducted according to the Study Plan and procedures described in the Guideline 201 of the Organisation for Economic Co-operation and Development (OECD, 2011). The 72-hours EyC50 value of test substance, obtained in this study with Pseudokirchneriella subcapitata, was 10.44 mg/L (95% confidence limits = 8.46 to 12.88 mg/L) and the 72-hours ErC50 value was 84.64 mg/L (95% confidence limits = 66.76 to 107.31 mg/L). The highest concentration of the test substance in which was not observed any statistically significant adverse effect on algal growth (NOEC) over the test period (72 hours) was 1 mg/L and the lowest test substance concentration at which was observed significant reducing effect on growth (LOEC) was 3.2 mg/L.
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