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EC number: 701-016-7
CAS number: -
No data on chronic toxicity to fish is available for HiMO LAB. Data from LAB (CAS no: 67774-74-7) as structural analogue was used to understand the chronic toxicity profile of substance to fish. The 14-day NOEC value for LAB was > 10 ug/L. As a consequence, due to the extremely low water solubility, the chronic toxicity is above the water solubility (<0.1 mg/L).
C16-24 alkyl derivatives are also known as High Molecular Weight Linear
Alkylbenzenes (HiMo LAB). The substance is a UVCB. Because of their
high molecular weight, they are very similar in composition and
properties to the heavy alkylate bottoms (HAB). Based on these
structural and functional similarities, data on LAB (CAS no: 67774-74-7)
being registered under REACH, LAB Alkylate Bottoms (CAS no: 85117-41-5)
described in OECD SIDS dossier, and HAB (CAS no: 84961-70-6) being
registered under REACH are suitable as supporting studies in case where
specific data on the HiMo LAB is lacking.
toxicity of LAB to fish was determined in an extended acute study according
204 as indicated in 6.1.1. No adverse effects were observed for the
concentrations tested during the study period. A decrease in the test
substance concentration was observed within 24 hours (day 1 and day 14),
but the daily renewal of test solutions maintained the exposure to the
test substance. Both the LOEC and NOEC were higher than the solubility
concentration of >10 ug/L/day.
The EPISUITE QSAR modelling was used to predict the chronic toxicity
profile of HiMo LAB. Modelled toxicity values for HiMo LAB (C20 and C24
alkyl derv.) confirmed that the aquatic chronic toxicity value exceeds
(i) the predicted water solubility, indicating the substance is not
soluble enough to measure the predicted effect and (ii) the log Kow
cutoff value of 8.0 for chronic toxicity to fish
to data from analogue substances and QSAR modelling of HiMo LAB, the
substance does not demonstrate chronic aquatic toxicity at water soluble
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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