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EC number: 701-016-7
CAS number: -
C16-24 alkyl derivatives are also known as High Molecular Weight Linear
Alkylbenzenes (HiMo LAB). The substance is a UVCB. Because of their
high molecular weight, they are very similar in composition and
properties to the heavy alkylate bottoms (HAB). Based on these
structural and functional similarities, data on LAB (CAS no: 67774-74-7)
being registered under REACH, LAB Alkylate Bottoms (CAS no: 85117-41-5)
described in OECD SIDS dossier, and HAB (CAS no: 84961-70-6) being
registered under REACH are suitable as supporting studies in case where
specific data on the HiMo LAB is lacking.
To assess the genetic toxicity profile of the substance, structral
analogue approach was used from HAB
(CAS no: 84961-70-6), LAB Alkylate
Bottoms (CAS no: 85117-41-5) and Benzene,
C10-16 alkyl derivs. (CAS no: 68648-87-3).
The study examined the mutagenic potential of the HAB according to EWG
guideline. Salmonella typhimuirum strains TA1538, TA1537, TA1535, TA98,
and TA100 were exposed to concentrations of 8, 40, 200, 1000, 5000
ug/plate of test substance in acetone in both the presence and absence
of S9. Positive control substances were nitroflourene, sodium azide, or
aminoacridine. Cultures were tested in triplicate for mutation
frequency. No treatment cultures showed mutation frequencies
significantly greater than negative controls. Positive controls showed
significantly greater mutation frequencies over negative controls,
therefore the test was valid. The test substance is not mutagenic in
either the presence or absence of metabolic activation.
The study examined the potential for LAB
Alkylate Bottoms to cause mutations according to OECD guideline
473. Chinese hamster ovary (CHO) cells were exposed to concentrations of
5.0-80.0 nL/mL of test substance both in the presence and absence of
metabolic activation. After the exposure period, the cells were examined
for chromosomal aberrations. Ethylmethanesulfonate and cyclophosphamide
were used as positive control substances. No increases in chromosomal
aberrations were seen in either the presence or absence of metabolic
activation. The test substance is not mutagenic.
The study examined the potential of Benzene,C10-16
alkyl derivs. (Alkylate 225) to cause mutations in mammalian
cells according to OECD guideline 476. Chinese hamster ovary cells were
exposed to concentrations of 100-2000 microliter/mL of test substance
both in the presence and absence of metabolic activation. Ethanol was
used as a vehicle. Ethylmethanesulfonate, benzo(a)pyrene, and
dimethylnitrosamine were used as positive controls. Cytotoxicity was
seen at concentrations of 0.5 mg/mL and above both with and without
metabolic activation. No significant increase in mutation frequencies
was seen in treatment groups. The test substance is not mutagenic to
Short description of key information:
No study on mutagenicity is available with the substance. HAB (CAS no: 84961-70-6), LAB Alkylate Bottoms (CAS no: 85117-41-5) and Benzene,C10-16 alkyl derivs. (CAS no: 68648-87-3) were used to cover this endpoint as structural analogue substances. According to the in vitro mutagenicity test results (Ames test, chromosomal aberration test, gene mutation test), the substance is considered to be not mutagenic and does not need to be classified for genotoxicity.
According to the in vitro mutagenicity test results (Ames test,
chromosomal aberration test, gene mutation test) from structural
analogue substances, the substance is considered to be not mutagenic and
does not need to be classified for genotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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