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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

dermal absorption, other
in silico
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
March 04, 2019
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
See the attached justification.

Data source

Referenceopen allclose all

Reference Type:
other: software
IH SkinPerm v2.04
AIHA Exposure Assessment Strategies Committee (EASC) and the Dermal Project Team (DPT) in collaboration with Wil ten Berg
Bibliographic source:
Tibaldi, R., ten Berge, W., Drolet, D.. IH SkinPerm v2.0 Reference Manual.
Reference Type:
other company data
Report date:

Materials and methods

Test guideline
other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
See the justification for type of information.

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl succinate
EC Number:
EC Name:
Diethyl succinate
Cas Number:
Molecular formula:
1,4-diethyl butanedioate

Results and discussion

Percutaneous absorption
Time point:
2 h
Deposition dose: 4993 mg (instantaneous)
<= 0.036 mg cm-2 h-1

Any other information on results incl. tables



EC name: diethyl succinate

CAS number: 123-25-1

Molecular weight: 174.19

Temperature: 20 deg C

Vapour Pressure (exp.): 5.9 Pa

Water solubility (exp.): 20100 mg/L

Log Kow (exp., skin, pH= 5.5): 1.4

Density (exp.): 1040.2 mg/cm3

Melting Point (exp.): -29 deg C

Scenario parameters

Istantaneous deposition dose(1): 4993 mg

Affected skin area(2): 1000 cm2

Maximum skin adherence(3): 7 mg/ cm2

Thickness of stagnant air(4): 1 cm

Weight fraction(5): 1

Timing parameters

- Start deposition: 0 hr

- End time observation: 2 hr

Report parameters

- Calculation intervals/hours: 7200

- Report intervals/hours: 60

(1) The instantaneous dose may occur by a splash or direct contact. The maximum amount of substance remaining on the skin is limited to 25 times the affected skin area (cm2). In case of instantaneous exposure, the duration of deposition and the dermal deposition rate are not considered in the calculation.

Approximately 2 mL of a liquid having a viscosity similar to water will practically wet the palms of two hands (ca. 420 cm2). So 4.8 mL will wet all the skin surface of both hands; the expected more liquid will be excess and wash/fall off.

(2) Estimated skin surface of two hands of an adult. The assumed maximum full body surface of an adult, is 20000 cm2. The minimum is set to 0.1 cm2, the fingertip in contact with liquid or solid.

(3) In case of liquids any value between 0 and 7 mg/cm2, and in case of solids any value between 0 and 3 mg/cm2 is allowed. This value means that the mass of the substance on the skin surface will not exceed the input value. If deposition results in an increased mass on the skin above the input vale, it is assumed that the surplus gets lost from the skin.

(4) Average thickness of air layer around the body accounting for diffusive resistance of substance in air through work clothing. Apply 3 cm. in case of light clothes and 1 cm in case of nude skin.

(5) The fraction of the substance within the mixture based on weight. It means the weight of the substance divided by the weight of the solution it is in. An example may be 0.8 for a highly concentrated solution.


Deposition: Instantaneous

Tot. Deposition: 4993 mg

End time observation: 2 hr


Fraction absorbed: 2.8%

Amount absorbed: 141 mg

Lag time stratum corneum: 32.1 min.


Max. derm. abs.: 0.0361 mg/cm2/hr

Max. derm. abs. for 2000 cm2in 1 hour (from liquid): 72.1 mg

Dermal/Respiratory uptake ratio (from airborne vapour): R= 0.79


RX: total dermal absorption by dermal exposure to airborne vapour

X: total inhalation absorption from airborne vapour

Assuming that Fully Respiratory Protection provides 100% efficiency:

Protection from respirator= 100*X/(RX+X)= 100/(R+1)= 100/1.79=55.9%

protection against overexposure to the substance in the form of vapour due to dermal vapour absorption over whole body surface.

Applicant's summary and conclusion

The dermal absorption of diethyl succinate leads to the following results, obtained using the SkinPerm v2.04 model according to the input data:

Fraction absorbed: 2.8%
Amount absorbed: 141 mg
Lag time stratum corneum: 32.1 min.

Max. derm. abs.: 0.0361 mg/cm2/hr
Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 72.1 mg

Dermal/Respiratory uptake ratio (from airborne vapour): R= 0.79
Executive summary:

In-silico evaluation of dermal absorption shows that after 2 hours a small amount of deposited substance is absorbed within viable epidermis and therefore enter in systemic circulation.