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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Fragrance Raw Materials Monographs - Diethyl Succinate
Author:
Anon.
Year:
1978
Bibliographic source:
Food Cosmet. Toxicol. 16 (Suppl.1): 707, 1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No more details available, database match.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl succinate
EC Number:
204-612-0
EC Name:
Diethyl succinate
Cas Number:
123-25-1
Molecular formula:
C8H14O4
IUPAC Name:
1,4-diethyl butanedioate
Test material form:
liquid

Test animals

Species:
rabbit

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
discriminating dose
Effect level:
>= 5 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Median lethal dose (LD50) in the rabbit following demal administration is reported to be in excess of 5000 mg/kg bw.
Executive summary:

Median lethal dose (LD50) in the rabbit following demal administration is reported to be in excess of 5000 mg/kg bw.