Registration Dossier
Registration Dossier
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EC number: 208-237-3 | CAS number: 517-28-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Haematoxylin
- EC Number:
- 208-237-3
- EC Name:
- Haematoxylin
- Cas Number:
- 517-28-2
- Molecular formula:
- C16H14O6
- IUPAC Name:
- haematoxylin
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- <= 0.3
- Temp.:
- 30 °C
- pH:
- ca. 6.9
Applicant's summary and conclusion
- Conclusions:
- Under the chromatographic conditions specified, the test substance eluted as 4 peaks on the ultraviolet (UV) detector. The corresponding Log Pow for the test substance by UV ranged from unretained (< formamide) to a value lower than 0.3.
The partition coefficient (log Pow) of test item “Hematoxylin HPL” was considered to be lower than 0.3 (4 compounds) within a range ± 0.1 log at 30 ± 1°C under the analytical conditions. - Executive summary:
The partition coefficient (log Pow) of test item “Hematoxylin HPL” was considered to be lower than 0.3 (4 compounds) within a range ± 0.1 log at 30 ± 1°C under the analytical conditions.
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