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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
16 Feb - 20 Feb 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
not specified
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
5.7
Temp.:
23 °C
Remarks on result:
other: pH not reported

Final Result

The HPLC method revealed a n-octanol/water partition coefficient (log Pow) for the test substance:

log Pow (Perlastan SCV) = 5.7 (at 23±1°C)

The worst case log Pow calculated from the retention time of the peak cut-off was 6.8. The averaged log Pow including the retention time from the start to the peak cut-off was 5.0.

 

Individual results

The test results displayed an average log Pow of 5.7±0.3.

Table : The calculated log Pow values for the peak of Perlastan SCV

               start      cut-off  peak

               5.0         6.3         5.7

               5.4         6.8         5.8

               5.4         6.4         5.7

 

It was not possible to calculate a weighted average since the single peaks of Perlastan SCV components could not be distinguished.

 

 

Description of key information

Log Kow is 5.7 at 23 ºC (OECD 117, HPLC method).

Log D values (QSAR, SPARC v4.6):

pH 4: 5.06 - 6.06

pH 7: 2.4 - 3.4

pH 9: 1.53 - 2.54

Key value for chemical safety assessment

Log Kow (Log Pow):
5.7
at the temperature of:
23 °C

Additional information