Reaction mass of stearoyl sarcosine and palmitoyl sarcosine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 Feb - 9 Mar 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

not specified

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

2.86 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 000 mg/L

Incubation duration:

24 h

Temp.:

19.7 °C

pH:

5.2

Remarks on result:

other: Key value is maximum solubility

Water solubility:

1.46 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 000 mg/L

Incubation duration:

48 h

Temp.:

19.7 °C

pH:

5.2

Water solubility:

1.09 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 000 mg/L

Incubation duration:

72 h

Temp.:

19.7 °C

pH:

5.2

Water solubility:

1.22 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

50 mg/L

Incubation duration:

72 h

Temp.:

19.7 °C

pH:

5.2

Remarks on result:

other: Additional test A: stored at 20 C only.

Water solubility:

0.38 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

100 mg/L

Incubation duration:

10 min

Temp.:

19.7 °C

pH:

5.2

Remarks on result:

other: Additional test B: conditioned flask

Results - Test conditions

The measured parameters of all studies were in accordance to the OECD Guideline 105 (OECD 1995). The pH was 5.2 and the temperature was 19.7 °C in the mixture of all studies. The conductivity of the used deionized water was 0.8 µS/cm.

 

Preliminary Test Results

The dissolution of the test substance was not visually detectable.

Main Test Result

The measured concentration of the test substance decreased with an increasing dissolution duration in the climatic exposure test cabinet at 30 °C (see Table below). The highest measured concentration was 2.86 mg/L after 24 h dissolution at 30 °C. With increasing dissolution duration the measured concentration of dissolved Perlastan® SCV fractions decreased. After 48 h only 50% of the concentration, which was measured after 24 h, was dissolved. After 72 the dissolved concentration further decreased to 1.09 mg/L.

Duration (h)	Peak Area	Conc. (mg/L)
24	5816	2.86
48	641	1.46
72	359	1.09

Additional test A - Results

The additional test A showed a measured concentration of 1.22 mg/L for the dissolved Perlastan® SCV fractions after 72 h. After more than 72 h the measured concentration was below the LOQ (=0.47 mg/L).

 

Additional test B - Results

The measured concentrations after 10 minutes of stirring were 0.38 mg/L in the conditioned/saturated flask and 0.33 mg/L in the unconditioned flask. Both values were below the LOQ (LOD=0.20 mg/L).

 

Conclusion

For the determination of the water solubility of Perlastan® SCV several tests were conducted. This was done to describe the water solubility more precisely. The tests showed, that the maximum dissolution is reached within 24 h. Elongated dissolution durations (>24 h) did not lead to an increase in measured concentrations. Also after shorter dissolution durations (i.e. after 10 min) a lower dissolved concentration of Perlastan® SCV was measured.

The flask method revealed the following water solubility for the test substance:

 

Water solubility (Perlastan® SCV): 0.38-2.86 mg/L (at 20 °C, after 10 min-24 h)

 

The determination of the water solubility over longer study durations is biased by adsorption.

Description of key information

Water solubility is 2.86 mg/L at 20 ºC (OECD 105, flask method).

Key value for chemical safety assessment

Water solubility:

2.86 mg/L

at the temperature of:

20 °C

Additional information

Maximum dissolution is reached within 24 h, and the value is 2.86 mg/L at 20 °C.