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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 Feb - 9 Mar 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
2.86 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Incubation duration:
24 h
Temp.:
19.7 °C
pH:
5.2
Remarks on result:
other: Key value is maximum solubility
Water solubility:
1.46 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Incubation duration:
48 h
Temp.:
19.7 °C
pH:
5.2
Water solubility:
1.09 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 000 mg/L
Incubation duration:
72 h
Temp.:
19.7 °C
pH:
5.2
Water solubility:
1.22 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
50 mg/L
Incubation duration:
72 h
Temp.:
19.7 °C
pH:
5.2
Remarks on result:
other: Additional test A: stored at 20 C only.
Water solubility:
0.38 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
100 mg/L
Incubation duration:
10 min
Temp.:
19.7 °C
pH:
5.2
Remarks on result:
other: Additional test B: conditioned flask

Results - Test conditions

The measured parameters of all studies were in accordance to the OECD Guideline 105 (OECD 1995). The pH was 5.2 and the temperature was 19.7 °C in the mixture of all studies. The conductivity of the used deionized water was 0.8 µS/cm.

 

Preliminary Test Results

The dissolution of the test substance was not visually detectable.

Main Test Result

The measured concentration of the test substance decreased with an increasing dissolution duration in the climatic exposure test cabinet at 30 °C (see Table below). The highest measured concentration was 2.86 mg/L after 24 h dissolution at 30 °C. With increasing dissolution duration the measured concentration of dissolved Perlastan® SCV fractions decreased. After 48 h only 50% of the concentration, which was measured after 24 h, was dissolved. After 72 the dissolved concentration further decreased to 1.09 mg/L.

Duration (h)

Peak Area

Conc. (mg/L)

24

5816

2.86

48

641

1.46

72

359

1.09

Additional test A - Results

The additional test A showed a measured concentration of 1.22 mg/L for the dissolved Perlastan® SCV fractions after 72 h. After more than 72 h the measured concentration was below the LOQ (=0.47 mg/L).

 

Additional test B - Results

The measured concentrations after 10 minutes of stirring were 0.38 mg/L in the conditioned/saturated flask and 0.33 mg/L in the unconditioned flask. Both values were below the LOQ (LOD=0.20 mg/L).

 

Conclusion

For the determination of the water solubility of Perlastan® SCV several tests were conducted. This was done to describe the water solubility more precisely. The tests showed, that the maximum dissolution is reached within 24 h. Elongated dissolution durations (>24 h) did not lead to an increase in measured concentrations. Also after shorter dissolution durations (i.e. after 10 min) a lower dissolved concentration of Perlastan® SCV was measured.

The flask method revealed the following water solubility for the test substance:

 

Water solubility (Perlastan® SCV): 0.38-2.86 mg/L (at 20 °C, after 10 min-24 h)

 

The determination of the water solubility over longer study durations is biased by adsorption.

Description of key information

Water solubility is 2.86 mg/L at 20 ºC (OECD 105, flask method).

Key value for chemical safety assessment

Water solubility:
2.86 mg/L
at the temperature of:
20 °C

Additional information

Maximum dissolution is reached within 24 h, and the value is 2.86 mg/L at 20 °C.