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EC number: 947-850-7 | CAS number: -
Table 1: Inhibition (%) of microbial respiration after 3 h of incubation
Table 1: Inhibition of microbial respiration
Consumption Rate (mg/L*h)
NOEC (3 h) = 10 mg/L (OECD 209, activated sludge); read-across
No studies investigating the toxicity to microorganisms are available for Reaction mass of N-(1-oxooctadecyl)sarcosine and N-hexadecanoyl-N-methylglycine (EC 947-850-7). Therefore, in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) was conducted.
The chemical properties of the target and source substance are similar due to the structural similarities, i.e., sarcosine head group and the hydrocarbon tail. In addition, due to the pka of the target substance (pKa = 3.96, major constituent), at physiological pH values (above 6) the target substance is expected to be in the anionic form, as are the source substances. As a result, the chemistry of the target and source substance, in solution (above pH 6), are expected to be similar. Thus, the source substance is considered suitable representative for the evaluation of the toxicity to microorganisms of the target substance. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.
The key study conducted with the source substance N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) was carried out under GLP conditions according to OECD guideline 209. Effects on the respiration rate of microorganisms were observed at concentrations of 32 mg/L and above (nominal), leading to an estimated EC50 (3 h) of 1300 mg/L (extrapolated) and a NOEC (3 h) of 10 mg/L.
The supporting study conducted with the source substance N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) according to OECCD guideline 209 did not follow GLP standards. Five test concentrations (1.1, 3.3, 10.7, 32.0, 100.2 mg/L) were inoculated with activated sludge. In this study, the IC50 (3 h) for respiration inhibition was above the highest tested concentration of 100 mg/L.
Based on the available results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure and chemistry, it can be concluded that Reaction mass of N-(1-oxooctadecyl)sarcosine and N-hexadecanoyl-N-methylglycine (EC 947-850-7) will exhibit comparable effects on activated sludge microorganisms.
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