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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data waiving: Data from handbook or collection of data

Data source

Reference
Title:
SIAM 29, 20-22 October 2009, SIDS INITIAL ASSESSMENT PROFILE

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
In bacterial reverse mutation assays with Salmonella typhimurium and E. coli, HMDZ was negative both with and without metabolic activation. Mammalian gene mutation assays with L5178Y mouse lymphoma cells were negative both with and without metabolic activation. An in vitro chromosomal aberrations test using HMDZ was negative both with and without metabolic activation. Based on these results, HMDZ is considered to be non-genotoxic in vitro