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EC number: 701-301-6
CAS number: -
The acute dermal toxicity of the test item was determined in accordance
to the OECD Guideline 402 with GLP. The test item at a single dose of
2000 mg/kg b.w. was applied to the shaved dorsal area of the trunks of 5
males and 5 females rats for 24 hours. After the application of the test
item, the animals were observed for 14 days. General and detailed
clinical observations of all animals were performed daily during the
entire experiment. Body weights of the animals were determined on days 0
(directly before the application of the test item), 7, and 14. After the
14-day observation period, the animals were euthanized, dissected, and
subjected to detailed gross examinations. The animals did not exhibit
any general clinical signs. No pathological changes on the treated skin
were noticed. All animals survived the experiment. These results
indicate that the acute dermal LD50 of the test item is > 2000 mg/kg bw
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