Registration Dossier
Registration Dossier
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EC number: 205-218-1 | CAS number: 135-76-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- (Only 2 strains were tested)
- Principles of method if other than guideline:
- Method: preincubaton
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium 6-hydroxynaphthalene-2-sulphonate
- EC Number:
- 205-218-1
- EC Name:
- Sodium 6-hydroxynaphthalene-2-sulphonate
- Cas Number:
- 135-76-2
- Molecular formula:
- C10H7NaO4S
- IUPAC Name:
- sodium 6-hydroxynaphthalene-2-sulphonate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA 98, TA 100.
- Metabolic activation:
- with and without
- Metabolic activation system:
- -S9 and +S9 were tested.
- Test concentrations with justification for top dose:
- 0-10000 (0, 50, 100, 500, 1000, 5000, 10000) ug/plate were tested
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium, other: TA 98, TA 100,
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The test item did not show any mutagenic effect under test conditions, with and without metabolic activation.
Applicant's summary and conclusion
- Conclusions:
- The test item did not show any mutagenic effect under test conditions, with and without metabolic activation.
- Executive summary:
The Ames test was carried out with the test item using Salmonella typhimurium strains TA 98, TA 100. The test was performed with and without matabolic activation. The concentrations were 0-10000 (0, 50, 100, 500, 1000, 5000, 10000) µg/plate.
The substance did not show any mutagenic effect under test conditions.
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