Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
July 27, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
March 04, 2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Version / remarks:
August 1996
Deviations:
no
GLP compliance:
yes
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium diisopropylnaphthalenesulphonate
EC Number:
215-343-3
EC Name:
Sodium diisopropylnaphthalenesulphonate
Cas Number:
1322-93-6
Molecular formula:
C16H20O3S.Na
IUPAC Name:
sodium diisopropylnaphthalene-sulfonate
Test material form:
solid: particulate/powder
Details on test material:
white to off-white lumps

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
>= 2.6
Temp.:
20 °C
Remarks on result:
other: pH not reported
Details on results:
The octanol solubility of the test item at 20°C was ≥ 777 g/L.
The Pow, calculated as the quotient of the n-octanol and critical micelle concentration, is ≥ 3.7  102. It corresponds with a log Pow value of ≥ 2.6.

Applicant's summary and conclusion

Conclusions:
The estimation method was applied for the determination of the partition coefficient (Pow) of CH04207.
The Pow value of the test item at 20°C was ≥ 3.7 * 10^2.
It corresponds with a log Pow value of ≥ 2.6.