Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Remarks:
theoretical assessment
Type of information:
other: expert statement
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Theoretical assessment taking all currrently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

GLP compliance:
no

Results and discussion

Main ADME results
Type:
absorption
Results:
For risk assessment purposes, 50% is used for oral and dermal absorption and 10% for inhalation absorption

Applicant's summary and conclusion

Conclusions:
A toxicokinetic assessment was performed based on the available data of the substance. Based on the properties of the substance, absorption factors for this substance are derived to be 50% (oral), 10% (inhalation) and 50% (dermal) for risk assessment purposes. The bioaccumulation potential is expected to be high.

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